A SIMPLE TREATMENT REGIMEN

VOSEVI tablet
Not actual size

VOSEVI treatment is just one pill, once a day, taken with food for 12 weeks.

VOSEVI is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated) who have previously been treated with a Hep C regimen containing an NS5A inhibitor.

HOW SHOULD YOU
TAKE VOSEVI?

Take VOSEVI exactly as your healthcare provider tells you to take it.

  • Do not change your dose unless your healthcare provider tells you to.
  • Do not stop taking VOSEVI without first talking with your healthcare provider.
  • Take 1 VOSEVI tablet each day.
  • Take VOSEVI with food.
  • If you need to take an antacid medicine that contains aluminum or magnesium, take it either 4 hours before or 4 hours after you take your dose of VOSEVI.
  • It is important that you do not miss or skip doses of VOSEVI during treatment.
  • If you take too much VOSEVI, call your healthcare provider or go to the nearest hospital emergency room right away.
Learn about common side effects with VOSEVI

VOSEVI is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated) who have previously been treated with a Hep C regimen containing an NS5A inhibitor.

Important Safety Information

What is the most important information I should know about VOSEVI?

VOSEVI can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting VOSEVI treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with VOSEVI. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking VOSEVI.

Who should not take VOSEVI?

  • Do not take VOSEVI if you take medicines that contain rifampin (Rifater®, Rifamate®, Rimactane®, Rifadin®).

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TIPS TO HELP YOU REACH YOUR GOAL

You may want to work with your healthcare provider to make a plan to help you take your medicine every day.

  • If you’ve had problems taking medicines in the past, let them know. They want you to succeed as much as you do.
  • Keep asking questions. If there’s something you don’t understand, it’s OK to keep asking until you do.
  • Use the tips below to help you stay on track.
  • Take VOSEVI once a day exactly as prescribed.
  • Take VOSEVI with food at the same time every day.
  • Keep VOSEVI with your other daily medications.
  • Set your alarm clock or phone alarm as a daily reminder.
  • Leave a reminder note where you’ll be sure to see it.

With hepatitis C treatment, the most important thing a person can do for their best chance of achieving a cure is to not miss taking any of their medication—and to finish all of it.

Important Safety Information

What should I tell my healthcare provider before taking VOSEVI?

  • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection or liver problems other than hepatitis C infection; if you have severe kidney problems or are on dialysis; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if VOSEVI will harm your unborn baby or pass into your breast milk.
  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. VOSEVI and certain other medicines may affect each other, or may cause side effects.

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TAKING VOSEVI AND OTHER MEDICINES

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. This is because VOSEVI and certain other medicines may affect each other, or may cause side effects.

It is particularly important to tell your healthcare provider if you take amiodarone (Cordarone®, Nexterone®, Pacerone®).

  • VOSEVI, when taken in combination with amiodarone, a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with VOSEVI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

Do not take VOSEVI if you take medicines that contain rifampin (Rifater®, Rifamate®, Rimactane®, Rifadin®).

Keep a list of your medicines to show your healthcare provider and pharmacist.

  • You can ask your healthcare provider or pharmacist for a list of medicines that interact with VOSEVI.
  • Do not start taking a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to take VOSEVI with other medicines.

Taking VOSEVI with certain medicines for gas, indigestion, heartburn, or stomach ulcers

Before taking VOSEVI with these medicines, be sure to talk with your healthcare provider.

COMMON
BRAND NAMES
RECOMMENDATION
  • Mylanta®
  • Maalox TC®
  • Other antacids containing aluminum or magnesium hydroxide

Take 4 hours before or 4 hours after VOSEVI.

  • Pepcid® (famotidine)
  • Tagamet® (cimetidine)
  • Axid® (nizatidine)
  • Zantac® (ranitidine)

Talk to your healthcare provider about the dose and how to take it. For example, famotidine may be taken at the same time as VOSEVI or staggered from VOSEVI at a dose that does not exceed 40 mg twice daily.

Prilosec® (omeprazole)

Omeprazole 20 mg can be taken with VOSEVI.

Important Safety Information

What are the possible side effects of VOSEVI?

Serious side effects may also include:

  • Slow heart rate (bradycardia): VOSEVI, when taken in combination with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with VOSEVI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

The most common side effects of VOSEVI include headache, tiredness, diarrhea, and nausea.

Please see Important Facts about VOSEVI including Important Warning.

VOSEVI is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated) who have previously been treated with a Hep C regimen containing an NS5A inhibitor.

Important Safety Information

What is the most important information I should know about VOSEVI?

VOSEVI can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting VOSEVI treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with VOSEVI. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking VOSEVI.

Who should not take VOSEVI?

  • Do not take VOSEVI if you take medicines that contain rifampin (Rifater®, Rifamate®, Rimactane®, Rifadin®).

What should I tell my healthcare provider before taking VOSEVI?

  • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection or liver problems other than hepatitis C infection; if you have severe kidney problems or are on dialysis; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if VOSEVI will harm your unborn baby or pass into your breast milk.
  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. VOSEVI and certain other medicines may affect each other, or may cause side effects.

What are the possible side effects of VOSEVI?

Serious side effects may also include:

  • Slow heart rate (bradycardia): VOSEVI, when taken in combination with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with VOSEVI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

The most common side effects of VOSEVI include headache, tiredness, diarrhea, and nausea.

Please see Important Facts about VOSEVI including Important Warning.