FREQUENTLY ASKED QUESTIONS
(FAQs)

Your Hep C Specialist is a great resource for any information regarding Hep C or treatment with VOSEVI. In addition, you may be able to find the answers you need below.

If you require further assistance, speak with a VOSEVI Educator at 1-833-4-VOSEVI (1-833-486-7384), Monday through Friday from 9AM to 9PM Eastern Time, or contact your Hep C Specialist.

VOSEVI is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated) who have previously been treated with a Hep C regimen containing an NS5A inhibitor.

UNDERSTANDING
HEP C

ABOUT
VOSEVI

TREATMENT
WITH VOSEVI

    • What is hepatitis C (Hep C) and what effects can it have?

      Hepatitis C is a contagious liver disease that ranges in severity from a mild illness lasting a few weeks to a serious, lifelong illness that attacks the liver. It results from infection with the hepatitis C virus (HCV), which is spread through contact with the blood of an infected person. Most people who become infected with the Hep C virus go on to develop chronic (or long-lasting) Hep C. Chronic Hep C progresses slowly and over time can cause liver damage or cirrhosis.

      If you have Hep C, you should work with your healthcare provider to assess your liver damage and discuss your treatment options before it progresses.

      What are the symptoms of Hep C?

      Called a “silent disease,” Hep C symptoms often do not appear or can be quite mild for years or even decades, even while liver damage is taking place. Most people with the Hep C virus go on to develop chronic Hep C and still have no symptoms or signs. Common symptoms of chronic Hep C can include fever, tiredness, loss of appetite, nausea, vomiting, dark urine, abdominal pain, joint pain, gray-colored stools, and jaundice (yellowing of skin or eyes).

      What is a Hep C genotype and why is this important?

      Just as there are different blood types, there are also different types of Hep C, called genotypes. It is important to know your genotype because it can help your healthcare provider choose the right treatment for you. Your healthcare provider can do a simple blood test to determine your Hep C genotype.

      Want to learn more?

      VISIT CLINICAL STUDY RESULTS

    • What is the most important information I should know about VOSEVI?

      VOSEVI can cause serious side effects, including:

      Hepatitis B virus reactivation: Before starting treatment with VOSEVI, your healthcare provider will do blood tests to check for hepatitis B virus infection. If you have ever had hepatitis B virus infection, the hepatitis B virus could become active again during or after treatment of hepatitis C virus with VOSEVI. Hepatitis B virus becoming active again (called reactivation) may cause serious liver problems including liver failure and death. Your healthcare provider will monitor you if you are at risk for hepatitis B virus reactivation during treatment and after you stop taking VOSEVI.

      Want to learn more about common side effects?

      VISIT COMMON SIDE EFFECTS
      What is VOSEVI?

      VOSEVI is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated) who have previously been treated with a Hep C regimen containing an NS5A inhibitor.

      It is not known if VOSEVI is safe and effective in children.

      Who should not take VOSEVI?

      Do not take VOSEVI if you take medicines that contain rifampin (Rifater®, Rifamate®, Rimactane®, Rifadin®).

      What should I tell my healthcare provider before taking VOSEVI?

      Before taking VOSEVI, tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection or liver problems other than hepatitis C infection; if you have severe kidney problems or you are on dialysis; or if you are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if VOSEVI will harm your unborn baby or pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take VOSEVI.

      Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. VOSEVI and other medicines may affect each other. This can cause you to have too much or not enough VOSEVI or other medicines in your body. This may affect the way VOSEVI or your other medicines work, or may cause side effects.

      Keep a list of your medicines to show your healthcare provider and pharmacist.

      • You can ask your healthcare provider or pharmacist for a list of medicines that interact with VOSEVI.
      • Do not start taking a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to take VOSEVI with other medicines.
      How should I take VOSEVI?
      • Take VOSEVI exactly as your healthcare provider tells you. Do not change your dose unless your healthcare provider tells you to.
      • Do not stop taking VOSEVI without first talking with your healthcare provider.
      • Take 1 VOSEVI tablet by mouth each day on a regular schedule.
      • Take VOSEVI with food.
      • If you need to take an antacid medicine that contains aluminum or magnesium, take it either 4 hours before or 4 hours after you take your dose of VOSEVI.
      • It is important that you do not miss or skip doses of VOSEVI during treatment.
      • If you take too much VOSEVI, call your healthcare provider or go to the nearest hospital emergency room right away.
      What are the possible side effects of VOSEVI?

      VOSEVI may cause serious side effects, including:

      • Hepatitis B virus (HBV) reactivation. See “What is the most important information I should know about VOSEVI?”
      • In people who had or have advanced liver problems before starting treatment with VOSEVI: rare risk of worsening liver problems, liver failure and death. Your healthcare provider will check you for signs and symptoms of worsening liver problems during treatment with VOSEVI. Tell your healthcare provider right away if you have any of the following signs and symptoms:
        • - nausea
        • - diarrhea
        • - tiredness
        • - yellowing of your skin or white part of your eyes
        • - bleeding or bruising more easily than normal
        • - confusion
        • - dark, black, or bloody stool
        • - loss of appetite
        • - dark or brown (tea-colored) urine
        • -
          swelling of your stomach area (abdomen) or pain on the upper right side of your stomach area
        • - sleepiness
        • - vomiting of blood
        • - lightheadedness
      • Slow heart rate (bradycardia). Vosevi treatment may result in slowing of the heart rate along with other symptoms when taken with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems. In some cases bradycardia has led to death or the need for a heart pacemaker when amiodarone is taken with medicines similar to VOSEVI that contain sofosbuvir. Get medical help right away if you take amiodarone with VOSEVI and get any of the following symptoms:
        • - fainting or near-fainting
        • - dizziness or lightheadedness
        • - not feeling well
        • - weakness
        • - extreme tiredness
        • - shortness of breath
        • - chest pains
        • - confusion
        • - memory problems
      • The most common side effects of VOSEVI include headache, tiredness, diarrhea, and nausea.
      • These are not all the possible side effects of VOSEVI.

      You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

      How should I store VOSEVI?
      • Store VOSEVI below 86˚F (30˚C).
      • Keep VOSEVI in its original container.

      Keep VOSEVI and all medicines out of the reach of children.

      What other general information should I know about the safe and effective use of VOSEVI?

      Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use VOSEVI for a condition for which it was not prescribed. Do not give VOSEVI to other people, even if they have the same symptoms that you have. It may harm them.

      You can ask your pharmacist or healthcare provider for information about VOSEVI that is written for health professionals.

      What are the ingredients in VOSEVI?

      Active ingredients: sofosbuvir, velpatasvir, and voxilaprevir
      Inactive ingredients: colloidal silicon dioxide, copovidone, croscarmellose sodium, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.

      The tablet film-coat contains: ferrosoferric oxide, iron oxide red, iron oxide yellow, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.

    • Why is it important that I work with a Hep C Specialist?

      Partnering up with a Hep C Specialist means you’ve got an expert on your side.

      Hep C Specialists are equipped to tell you about all of the treatment options that are available to you. Hep C Specialists include, but are not limited to, gastroenterologists (specialize in diseases that affect the digestive system) and hepatologists (specialize in diseases that affect the liver). Others who may treat Hep C include infectious diseases (ID) specialists; primary care physicians (PCPs), internal medicine specialists (internists) or family doctors; nurse practitioners (NPs), and physician assistants (PAs).

      Not currently working with a Hep C Specialist?

      FIND A HEP C SPECIALIST
      What should I bring with me when I visit my Hep C Specialist?

      When visiting your Hep C Specialist, be prepared to share your medical history, including details of your previous Hep C treatment. It's a good idea to bring along your medical records, a list of any and all medicines you are taking (prescription and/or over-the-counter medicines, vitamins, and herbal supplements) and write down any questions you may have for your specialist. Be prepared to talk about any symptoms you may be experiencing, even if you don’t think they seem related to your liver or hepatitis C. You may wish to write down this information prior to your visit and bring it with you.

      Need more help preparing to speak with your Hep C Specialist?

      DOWNLOAD YOUR CONVERSATION GUIDE
      How do I fill my VOSEVI prescription?

      If you and your Hep C Specialist decide VOSEVI is right for you, your Hep C Specialist will submit your prescription directly to a specialty pharmacy. Specialty pharmacies provide medications that have special delivery, storage, or administration requirements, and typically deliver medicine directly to patients by US mail or a delivery service.

      Want to learn more? Speak with a VOSEVI Support Path® program navigator at 1-855-7-MYPATH (1-855-769-7284).

      What is a specialty pharmacy?

      Specialty pharmacies provide medications that have special delivery, storage, or administration requirements, and deliver medicine directly to patients by US mail or a delivery service.

      Want to learn more? Speak with a VOSEVI Support Path® program navigator at 1-855-7-MYPATH (1-855-769-7284).

      Are there ways I could save money on VOSEVI?

      For information about ways you could save money on VOSEVI, visit Financial Assistance & Insurance Support or call 1-855-7-MYPATH (1-855-769-7284).

      You may be eligible to pay as little as $5 per co-pay for VOSEVI. Restrictions apply.

      CHECK YOUR ELIGIBILITY FOR A VOSEVI CO‑PAY COUPON
      How do I find out if my insurance covers VOSEVI?

      One way is by contacting VOSEVI Support Path®, where a program navigator can assist you with this and other insurance-related questions. Call VOSEVI Support Path at 1-855-7-MYPATH (1-855-769-7284) and inform the VOSEVI Support Path navigator that you want to complete a benefits investigation. Provide the VOSEVI Support Path navigator with your name and address, the name and address of your prescribing doctor, your pharmacy benefit card, and your medical benefit card. You may also contact your insurance company directly.

      Need more help preparing for your benefits investigation?

      VISIT FINANCIAL ASSISTANCE & INSURANCE SUPPORT
      How long will it take to receive verification of my benefits from VOSEVI Support Path®?

      If you or your healthcare provider have contacted VOSEVI Support Path and requested verification of your insurance coverage, you will receive verification of your benefits in a follow-up phone call from VOSEVI Support Path within 24–48 hours. Your physician will receive a written benefit verification summary via fax within 48 hours.

      Need more help navigating your insurance coverage?

      VISIT FINANCIAL ASSISTANCE & INSURANCE SUPPORT
      What if my insurance doesn’t cover VOSEVI?

      You still might be eligible for financial assistance. Visit Financial Assistance & Insurance Support or speak with a VOSEVI Support Path® program navigator at 1-855-7-MYPATH (1-855-769-7284) to see what options might be available to you.

      After I have finished treatment, how long will it take to find out if I am cured?

      Being “cured” of Hep C is defined as when the virus cannot be detected in the blood when measured at least three months after treatment is completed. Your doctor will use a simple blood test to determine your success with treatment.

      Want to learn more?

      VISIT TAKING VOSEVI

VOSEVI is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1, 2, 3, 4, 5, or 6 infection with or without cirrhosis (compensated) who have previously been treated with a Hep C regimen containing an NS5A inhibitor.

Important Safety Information

What is the most important information I should know about VOSEVI?

VOSEVI can cause serious side effects, including:

  • Hepatitis B virus reactivation: Before starting VOSEVI treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during or after treatment with VOSEVI. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during treatment and after you stop taking VOSEVI.

Who should not take VOSEVI?

  • Do not take VOSEVI if you take medicines that contain rifampin (Rifater®, Rifamate®, Rimactane®, Rifadin®).

What should I tell my healthcare provider before taking VOSEVI?

  • Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection or liver problems other than hepatitis C infection; if you have severe kidney problems or are on dialysis; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if VOSEVI will harm your unborn baby or pass into your breast milk.
  • Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. VOSEVI and certain other medicines may affect each other, or may cause side effects.

What are the possible side effects of VOSEVI?

Serious side effects may also include:

  • In people who had or have advanced liver problems before starting treatment with VOSEVI: rare risk of worsening liver problems, liver failure and death.
    Your healthcare provider will check you for signs and symptoms of worsening liver problems during treatment with VOSEVI. Tell your healthcare provider right away if you have any of the following: nausea; tiredness; yellowing of your skin or white part of your eyes; bleeding or bruising more easily than normal; confusion; dark, black or bloody stool; loss of appetite; diarrhea; dark or brown (tea-colored) urine; swelling of your stomach area (abdomen) or pain on the upper right side of your stomach area; sleepiness; vomiting of blood; or lightheadedness.
  • Slow heart rate (bradycardia): VOSEVI, when taken in combination with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases, slow heart rate has led to death or the need for a heart pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with VOSEVI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.

The most common side effects of VOSEVI include headache, tiredness, diarrhea, and nausea.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Important Facts about VOSEVI including Important Warning.