TAKING VOSEVI AND OTHER MEDICINES
Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. This is because VOSEVI and certain other medicines may affect each other, or may cause side effects.
It is particularly important to tell your healthcare provider if you take amiodarone (Cordarone®, Nexterone®, Pacerone®).
VOSEVI, when taken in combination with amiodarone, a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with VOSEVI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.
Do not take VOSEVI if you take medicines that contain rifampin (Rifater®, Rifamate®, Rimactane®, Rifadin®).
Keep a list of your medicines to show your healthcare provider and pharmacist.
- You can ask your healthcare provider or pharmacist for a list of medicines that interact with VOSEVI.
- Do not start taking a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to take VOSEVI with other medicines.
Taking VOSEVI with certain medicines for gas, indigestion, heartburn, or stomach ulcers
Before taking VOSEVI with these medicines, be sure to talk with your healthcare provider.
- Maalox TC®
- Other antacids containing aluminum or magnesium hydroxide
Take 4 hours before or 4 hours after VOSEVI.
- Pepcid® (famotidine)
- Tagamet® (cimetidine)
- Axid® (nizatidine)
- Zantac® (ranitidine)
Talk to your healthcare provider about the dose and how to take it. For example, famotidine may be taken at the same time as VOSEVI or staggered from VOSEVI at a dose that does not exceed 40 mg twice daily.
Omeprazole 20 mg can be taken with VOSEVI.
Important Safety Information
What are the possible side effects of VOSEVI?
Serious side effects may also include:
- In people who had or have advanced liver problems before starting treatment with VOSEVI: rare risk of worsening liver problems, liver failure and death.
Your healthcare provider will check you for signs and symptoms of worsening liver problems during treatment with VOSEVI. Tell your healthcare provider right away if you have any of the following: nausea; tiredness; yellowing of your skin or white part of your eyes; bleeding or bruising more easily than normal; confusion; dark, black or bloody stool; loss of appetite; diarrhea; dark or brown (tea-colored) urine; swelling of your stomach area (abdomen) or pain on the upper right side of your stomach area; sleepiness; vomiting of blood; or lightheadedness.
- Slow heart rate (bradycardia): VOSEVI, when taken in combination with amiodarone (Cordarone®, Nexterone®, Pacerone®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases, slow heart rate has led to death or the need for a heart pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with VOSEVI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.
The most common side effects of VOSEVI include headache, tiredness, diarrhea, and nausea.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Important Facts about VOSEVI including Important Warning.